About
The Melbourne Mathematical Biology (MMB) Group is a part of the School of Mathematics and Statistics at The University of Melbourne. Our group is passionate about using advanced mathematical, statistical and computational methods to model and analyse complex biological systems across seven themes. We support several event series, including the Melbourne Mathematical Biology seminar series. In 2021, we are hosting the Special Emphasis Year on “Biological Dynamics: Mathematics of Cellular Systems to Epidemics” which is supporting events such as the Mathematical Biology Special Interest Group Annual Meeting.
These systems span across many scales, including micro scale, where we can determine how individual bacteria sense their local environment to search for nutrients:
To the continental scale, where we can observe how antimalarial drug resistance is predicted to spread throughout populations:
Staff
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Barry Hughes
Barry is a professor at the School of Mathematics and Statistics at the University of Melbourne. He has broad interests in applied mathematics and mathematical biology. Webpage: https://researchers.ms.unimelb.edu.au/~barrydh@unimelb/ Email: barrydh@unimelb.edu.au
Epidemiological... -
Douglas Brumley
Dr. Douglas Brumley is a Senior Lecturer in Applied Mathematics and leads an interdisciplinary research group at the interface of mathematics, biophysics and microbial Ecology. The Brumley lab utilises mathematics, microfluidics and microscopy to study a range of dynamic processes in biology including bacterial motility, symbioses, nutrient cycling and flows around coral reefs. Email: d.brumley@unimelb.edu.au
Biological flui... -
Edmund Crampin
Professor Edmund Crampin is Rowden White Chair of Systems Biology in the School of Mathematics and Statistics and the School of Chemical and Biomedical Engineering. Edmund directs the Systems Biology Lab, which develops mathematical models to investigate regulatory processes and pathways underlying biological processes and human disease. Current projects include developing energy-based approaches to modelling in systems and synthetic biology; …
Systems biology... -
James McCaw
Professor James McCaw is a Professor in Mathematical Biology in the School of Mathematics and Statistics and the Modelling and Simulation Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health. His interests span from modelling host-pathogen-drug dynamics, with a focus on influenza and malaria, to developing public health control strategies for emerging and re-emerging infectious diseases. Website: …
Within-host dyn... -
James Osborne
James is a Senior Lecturer in Applied Mathematics at the School of Mathematics and Statistics at the University of Melbourne. His work is at the interface between applied mathematics, scientific computing and biology: he uses mathematical and scientific computing techniques to develop reliable, robust and efficient simulations of multiscale biological and physiological phenomena. James has published over 40 peer reviewed …
Tissue dynamics... -
James Walker
Dr. James Walker is a Research Fellow in the School of Mathematics and Statistics at the University of Melbourne. In 2020, they completed a PhD at the University of Adelaide which developed Bayesian inference and model selection methods for emerging infectious diseases. Subsequently, they joined the Australian COVID-19 modelling efforts where their research informed the Commonwealth Government's early public health …
Epidemiological... -
Jared M. Field
Dr Jared M. Field is a McKenzie Fellow broadly interested in the intersection of mathematics, ecology and evolutionary biology. He is currently working on human life-history theory, Bayesian modelling of behaviour, and Indigenous Australian marriage rules and genetics. Webpage: https://blogs.unimelb.edu.au/jared-field/#tabmain Email: jared.field@unimelb.edu.au
Mathematical ec... -
Jennifer Flegg
Jennifer is an Associate Professor in applied mathematics in the School of Mathematics and Statistics at the University of Melbourne. Her research focuses on using mathematics and statistics to answer questions in biology and medicine. In particular, she develops mathematical models in areas such as wound healing, tumour growth and infectious disease epidemiology. Webpage: https://blogs.unimelb.edu.au/jennifer-flegg/ Email: Jennifer.flegg@unimelb.edu.au
Epidemiological... -
Michael Pan
Dr. Michael Pan is a Research Fellow at the Systems Biology Laboratory. His work makes use of energy-based approaches to develop mathematical models for a diverse range of applications in systems and synthetic biology. Current research interests include constructing large-scale dynamic models of biochemical pathways, understanding the relationship between energy and function in heart cells, and rationally designing enzymatic pathways …
Systems biology... -
Michael Stumpf
Professor Michael Stumpf holds the Chair in Theoretical Systems Biology in the School of BioSciences and in the School of Mathematics and Statistics. Michael’s work deals with the development of mathematical and statistical methods to infer the structure of mathematical models from data. His biological interest concerns cellular decision making processes, e.g. how does a single fertlised egg cell give …
Systems biology... -
Pengxing Cao
Pengxing Cao is a postdoctoral research fellow in the School of Mathematics and Statistics, The University of Melbourne. He obtained his PhD in mathematics at the University of Auckland, New Zealand in 2014. His PhD thesis looked at mathematical modelling of calcium oscillations in airway smooth muscle cells. Then he moved to Melbourne to work on infectious diseases modelling with …
Within-host dyn... -
Stuart Johnston
Dr Stuart Johnston is a DECRA Research Fellow in the School of Mathematics and Statistics at The University of Melbourne. Stuart graduated with a Bachelor of Mathematics (Hons) from the Queensland University of Technology. In 2017, he completed a PhD in Mathematical Biology at the Queensland University of Technology, focused on mathematical models of collective cell behaviour. Subsequently, Stuart joined the …
Biological flui...
Students
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Adriana Zanca
Adriana is a PhD student in the School of Mathematics and Statistics at the University of Melbourne under the supervision of Dr James Osborne and Assoc Prof Jennifer Flegg. Her work focuses on cell-based computational models of wound healing. She is particularly interested in how heterogeneities at a cell-scale change behaviour at a tissue scale. She has also worked with …
Tissue dynamics... -
Domenic Germano
Domenic is a PhD student at the School of Mathematics and Statistics at the University of Melbourne, working under the supervision of Dr James Osborne and Prof Edmund Crampin. His current work is on the development of a cell-based, deformable model of tissues, to understand the mechanics of the colonic crypt epithelium. Domenic has also previously worked on a cell-based model …
Tissue dynamics... -
Dominic Maderazo
Dominic Maderazo is a PhD student under the supervision of Jennifer Flegg at the University of Melbourne and Jonathan Keith at Monash University. His previous work includes multi-scale modelling of immune systems to investigate the effects of physiological changes may have on the effectiveness of the immune response. Currently, Dominic works on statistical methods for change point analysis and binary …
Systems biology... -
Jessica Crawshaw
Jessica is a final year PhD student at the School of Mathematics and Statistics at the University of Melbourne, working with Dr James Osborne and Prof Jennifer Flegg. During her PhD, Jessica has been developing a coupled fluid-structure-growth model of vascular regression to study the role of the local blood flow on cellular migration and capillary wall mechanics during development. …
Biological flui... -
Ke Li
Ke Li is a PhD student at the School of Mathematics and Statistics at the University of Melbourne, working with the Prof James McCaw and Dr Pengxing Cao. His current work is on the development of within-host dynamical models to understand essential interactions between influenza virus and immune responses. Email: kl2@student.unimelb.edu.au
Within-host dyn... -
Mahdieh Mahdavi
Mahdieh is a PhD student in the School of Mathematics and Statistics at the University of Melbourne under the supervision of Dr James Osborne and Assoc Prof Jennifer Flegg. Her research focuses on using cell-based mathematical modelling to understand the mechanics of the colonic crypt. Email: mmahdavi@student.unimelb.edu.au
Tissue dynamics... -
Md Nurul Anwar
Md Nurul Anwar is a PhD student in the School of Mathematics and Statistics under the supervision of A/Prof. Dr Jennifer Flegg, Prof. James McCaw, A/Prof. Roslyn Hickson and A/Prof. Jack Richards. His work focusses on Malaria specially Plasmodium Vivax dynamics. He is currently working on developing a simple model from a complex one that can capture similar dynamics. Email: mdnurul.anwar@student.unimelb.edu.au
Epidemiological... -
Punya Alahakoon
Punya is a PhD student in the School of Mathematics and Statistics at the University of Melbourne under the supervision of Prof. James McCaw and Prof. Peter Taylor. Her research focuses on using mathematics and statistics to understand the extinction of infectious diseases. Email: palahakoonmu@student.unimelb.edu.au
Epidemiological... -
Siluvai Antony Selvan
Antony is a Joint Ph.D. student at the School of Mathematics and Statistics at the University of Melbourne, working under the supervision of Dr. Douglas Brumley, Prof Linda Blackall, and Prof John Sader. His current work is on the Microscale fluid dynamics around coral surfaces, in particular, to understand the ciliary flows and its ecological consequences. Other than this, Antony …
Biological flui... -
Thomas Williams
Thomas is a PhD candidate under the supervision of Dr James Osborne and Prof James McCaw at the University of Melbourne. His work applies a temporospatial modelling approach to viral infections such as SARS-CoV-2 within tissue. An earlier project studied diffusion properties of carcinomas in cancer progression.
Within-host dyn...
Visitors & Affiliated Students
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Gopikrishnan C Remesan
Gopikrishnan is a PhD student in the joint research school IITB-Monash Research Academy under the supervision of Prof Jerome Droniou (Monash University), A/Prof Jennifer Flegg (The University of Melbourne), and Prof Neela Nataraj (IIT Bombay). Gopikrishnan focuses on a range of topics in applied mathematics such as mathematical modelling, scientific computing, and numerical analysis. In particular, he conceives mathematical models …
Visitors/Affili... -
Phillip Brown
Phillip Brown is a PhD candidate at the University of Adelaide, supervised by Dr Ed Green, Associate Professor Ben Binder (both UofA) and Dr James Osborne. His work focuses on cell-based modelling of buckling epithelial tissues, with particular application to the colonic crypt. Currently he is working on a new modelling approach that has a wide range of applications across the off-lattice …
Visitors/Affili... -
Sarah Belet
Sarah Belet is a MPhil student in the School of Mathematics, Monash University, and is supervised by A. Prof Jonathan Keith and A. Prof Jennifer Flegg. Her research looks at the spread of the bacteria Wolbachia within mosquito population as a means to suppress the spread of dengue fever.
Visitors/Affili...
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Biological fluid dynamics
Explains the mechanisms of fluid flow in biological systems and their interrelationship with physiological processes.
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Epidemiological dynamics
Informing policy and practice through the mathematical modelling of infectious diseases, with a focus on emerging and neglected tropical diseases, through the lenses of biosecurity and on health.
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Mathematical ecology and evolution
Mathematical modelling of problems at the intersection of ecology and evolution, to understand adaption and render hypotheses in this field more open to falsification.
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Multicellular biology
The use of numerical methods to understand the behaviour of multicellular systems, through computer aided simulation.
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Systems biology
Mathematical modelling to understand how the components of a biological system interact to generate the properties and physiological behaviour of that system.
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Tissue dynamics
A mechanistic description to understand tissue scale phenomena.
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Within-host dynamics
Describes the relation between a disease within a host and the response triggered.
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Theory of Living Systems seminar series
Jointly organised by groups at the University of New South Wales and the University of Melbourne, the Theory of Living Systems is a webcast seminar series based out of Australia and New Zealand. The aim is to promote cutting edge research at the interface of theory, computation and life science. For more information, please see Theory of Living Systems. Organisers: Dr Richard Morris, …
Events -
Melbourne Mathematical Biology seminar series
This seminar series is organised by the Melbourne Mathematical Biology group, and is supported by the Computational Biology Research Initiative. Featuring renowned speakers, the series covers applications of mathematics and computing to understand biological systems. To subscribe and receive email notifications about upcoming seminars, please see The School of Mathematics and Statistics Events page. Coordinator: Dr Douglas Brumley
Events
Special Emphasis Year supported events
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ANZIAM2021 – Mathematical Biology Special Interest Group Annual Meeting
In 2021, ANZIAM will be holding its annual conference virtually, and as a result the Mathematical Biology Special Interest Group (MBSIG) will also be meeting in a virtual setting. Theme Decision Making and Mathematical Biology Date Monday 8th of February 2021 Where This years MBSIG annual meeting will be held virtually on VirtualChair, in the Plenary Room. Schedule 9:00am-9:10am: Welcome 9:10am-10:10am: Keynote Presentation (Prof. Alex Mogilner, Courant Institute, New York …
Special Emphasi... -
Cell Motility in Dynamic Environments
"Cell Motility in Dynamic Environments" is the first of two MATRIX Research Programs, with the second being "Mathematics of Tissue Dynamics". This research program will specifically examine the intricate coupling between fluid mechanics, cell motility and active navigation, ubiquitous features of the microbial world. The participants will present novel mathematical and experimental approaches for studying cell dynamics in carefully controlled microenvironments, …
Special Emphasi... -
Mathematics of Tissue Dynamics
"Mathematics of Tissue Dynamics" is the second of two MATRIX Research Programs, with the first being "Cell Motility in Dynamic Environments". This program will see graduate students and world-leading mathematical modellers come together to collaborate in a week-long research intensive program, in the area of tissue dynamics. We will focus on multiple scales, incorporating many different modelling techniques. The aim of …
Special Emphasi...
Biological Dynamics: Mathematics of Cellular Systems to Epidemics
The School of Mathematics and Statistics 2021 Special Emphasis Year will be on “Biological Dynamics: Mathematics of Cellular Systems to Epidemics”. We will be constructing a program to build on and promote the internationally recognised expertise within the school in the multi-disciplinary field of Biological Dynamics.
The Special Emphasis Year will be led by A/Prof Jennifer Flegg and Dr Douglas Brumley, with core members Prof James McCaw, Prof Edmund Crampin, Prof Michael Stumpf, Prof Barry Hughes and Dr James Osborne.
The University’s Computational Biology Hallmark Research Initiative (CBRI) was established in 2014, and fostered a growing campus-wide community using mathematical, statistical and computational techniques to study biological systems.
A key outcome of the CBRI has been the identification and consolidation of two major areas of research strength across the University: ‘Statistical Genomics’ and ‘Biological Dynamics’ (the latter being research into biological systems in which the study of dynamics is the central unifying feature).
The COVID-19 pandemic has brought to the attention of the world the role that mathematical modelling can play in providing essential mechanistic understanding of biological systems. Prof James McCaw has been leading the mathematical modelling work that has helped guide the Australian response to the pandemic.
The mathematics behind modelling disease outbreaks will be a key theme of the Special Emphasis Year. The team will also be highlighting and building on other aspects of their research in areas including systems biology, multicellular biology, tissue dynamics, within-host dynamics and biological fluid dynamics.
Special Emphasis Year supported events
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ANZIAM2021 – Mathematical Biology Special Interest Group Annual Meeting
In 2021, ANZIAM will be holding its annual conference virtually, and as a result the Mathematical Biology Special Interest Group (MBSIG) will also be meeting in a virtual setting. Theme Decision Making and Mathematical Biology Date Monday 8th of February 2021 Where This years MBSIG annual meeting will be held virtually on VirtualChair, in the Plenary Room. Schedule 9:00am-9:10am: Welcome 9:10am-10:10am: Keynote Presentation (Prof. Alex Mogilner, Courant Institute, New York …
Special Emphasi... -
Cell Motility in Dynamic Environments
"Cell Motility in Dynamic Environments" is the first of two MATRIX Research Programs, with the second being "Mathematics of Tissue Dynamics". This research program will specifically examine the intricate coupling between fluid mechanics, cell motility and active navigation, ubiquitous features of the microbial world. The participants will present novel mathematical and experimental approaches for studying cell dynamics in carefully controlled microenvironments, …
Special Emphasi... -
Mathematics of Tissue Dynamics
"Mathematics of Tissue Dynamics" is the second of two MATRIX Research Programs, with the first being "Cell Motility in Dynamic Environments". This program will see graduate students and world-leading mathematical modellers come together to collaborate in a week-long research intensive program, in the area of tissue dynamics. We will focus on multiple scales, incorporating many different modelling techniques. The aim of …
Special Emphasi...
